Evidence of honey used for burns & wounds can be traced back centuries. From the Sumerians of Mesopotamia to the ancient Egyptians, Greeks, and Romans. Medicinal honey use has been mentioned in the Bible & Quran and is ingrained in ancient Ayurvedic & Chinese medicine practices. Today, it is recommended by dieticians and holistic doctors, used in hospitals, and even prescribed by some MDs!
In this article, we will tackle the following topics:
The Difference Between Raw Manuka & the Manuka Used in Hospitals:
You likely know what raw honey means: pure, unadulterated, not pasteurized or ever heated above hive temperature. You might not know that the only difference between raw manuka & the manuka used in hospitals is that the latter is typically treated with high heat or gamma radiation to “sterilize” the honey.
When it comes to the honey itself, there is no such thing as “medicinal or medical grade” honey. All real manuka honey from New Zealand has to meet strict testing & reporting requirements to leave the country. You can also find high MGO strengths in raw and sterilized honey options.
Sterilizing does kill the raw benefits, affecting the honey’s ability to provide nutrients like amino acids, vitamins & minerals, which speed healing. However, it does not affect the MGO content, which is one of the reasons manuka honey is used in hospital settings vs. other honey types.
Since manuka has a potent antibacterial effect, why does it need to be sterilized? If you ask, we don’t think it does. Numerous clinical trials use untreated honey, and none of the participants experienced infections. Additionally, raw honey has been used for so long on so many people without adverse side effects.
The other reason it is the honey of choice in medical settings is that manuka is the only honey with high levels of methylglyoxal (MGO). MGO is the anti-bacterial/microbial/inflammatory component of manuka.
Other honeys’ properties come from peroxide activity, which is short-lived in your body and is killed off by high heat. MGO has also been found to be more effective than standard honey for most medicinal uses.
What Strength Should You Use?
The strength you choose can vary depending on the severity of what you are treating. For instance, we use a low MGO (60+) on kitchen burns and minor scrapes, which works great. More severe cases might warrant higher activity.
Even though “medical grade” is not a recognized grade or system, you’ll still see the term floating around on a lot of packaging. We’ve seen it on the strengths of MGO 400+ and up, while other brands don’t disclose what strength manuka they are using. So, even if a product is labeled medical grade, you must always look for the MGO content to know what you are getting.
At PRI, we carry grades up to 1000+ MGO, which would be great for new surgical, severe, and non-healing wounds, in addition to the treatment recommended by your doctor.
Generally speaking, honey with an MGO of 400+ and up is recommended for either external purposes or more severe internal issues like significant inflammation, injury to the stomach lining due to other digestive problems, chemotherapy, and more. If your nutritionist wants you on an anti-inflammatory diet, adding high MGO-content honey to your routine could be very helpful.
For burns & wounds, it comes down to how your injury affects your quality of life & what you can afford to incorporate into your ongoing routine. We see many success stories with lower MGO content honey, while others need to step it up.
The Importance of Further Studies Relating to Manuka Honey, Burns & Wounds
There are centuries of data on the use of honey for medicinal purposes, along with a good number of promising current studies. It is clear we need more research on this topic, especially given what many experts are now calling the biggest threat to global health: antibiotic resistance.
Antibiotic resistance is thought to be caused by the extreme overuse of antibiotics and the ability of microorganisms, like bacteria to evolve to survive. More and more organisms are becoming antibiotic-resistant every day. This issue will affect everyone worldwide with higher death rates, higher costs, more hospital stays, and a wider spread of drug-resistant infections.
On the other hand, honey has never caused bacterial resistance and has been shown to be effective against many antibiotic-resistant organisms. Pseudomonas (the bacteria that cause pneumonia), staph infections, and MRSA are just three examples of antibiotic-resistant bacteria that manuka honey can treat.
New Research on Manuka Honey and Wound Healing
In recent years, scientific interest in Manuka honey for wound care has continued to grow. Modern studies are helping explain why Manuka honey has long been used in burn and wound treatment, particularly its ability to support healing while managing bacteria and inflammation.
A recent study using a porcine (pig skin) burn model, widely regarded as one of the closest comparisons to human skin, found that wounds treated with Manuka honey showed faster re-epithelialization and increased collagen formation compared to wounds treated with standard antibiotic ointments [1]. These markers are essential for proper skin regeneration and structural repair during burn healing.
Additional animal research has demonstrated that Manuka honey may help shorten healing time and improve tissue quality in burn wounds when used topically, reinforcing its potential role as a supportive treatment in wound care protocols [2].
The application of honey to burns & wounds has shown the following functions:
Antibacterial & Antimicrobial Support
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Helps fight harmful bacteria
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Effective against some antibiotic-resistant strains
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Helps reduce risk of infection
Anti-Inflammatory & Antioxidant Support
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Helps reduce inflammation
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Neutralizes free radicals
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May help reduce pain and swelling
Tissue Repair & Skin Regeneration
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Stimulates tissue repair processes
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Promotes epithelialization (new skin growth)
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Supports collagen formation
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May help reduce scar formation
Protective Barrier & Moisture Balance
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Creates a protective barrier over the wound
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Maintains a moist healing environment
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Helps clean and deodorize wounds
There are often multiple studies related to each function. You can see all of them, along with descriptive processes, here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158441/.
We also found this study on manuka honey for non-healing wounds interesting, though the mechanisms of healing are the same: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386265/.
Support for Chronic and Non-Healing Wounds
Beyond burns, clinical observations have shown promising results for Manuka honey in chronic and slow-to-heal wounds. In a clinical case series, patients with long-standing wounds experienced significant wound depth reduction and complete epithelialization after treatment with Manuka honey dressings, along with reduced inflammation and no increase in infection risk [3].
These findings suggest that Manuka honey may be particularly helpful in wounds where maintaining a balanced healing environment is critical.
Why Manuka Honey Works
Researchers attribute Manuka honey’s wound-healing potential to several key factors:
Its ability to help limit bacterial growth, including certain antibiotic-resistant strains [1][2][3]
Support for a moist wound environment, which is essential for tissue repair [1][3]
Potential to modulate inflammation, allowing the body to progress more efficiently through the healing process [2][3]
Unlike regular honey, Manuka honey retains its antibacterial activity even when diluted by wound moisture, making it uniquely suited for topical wound applications.
Burns vs. Wounds
Below, we will explore the different types of burns & wounds and when to seek medical attention. The practical functions of manuka honey on both types of injuries are the same, as well as how one would use honey to dress the injuries.
Types of Burns and When to Seek Medical Care
A burn is tissue damaged by heat. Burn treatment depends on the type of burn. Here are the four types:
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First-Degree Burns or Superficial Burns are mild. These cause pain and reddening of the outer layer of the skin or epidermis. Examples of these burns would be minor cooking burns or a good sunburn. No medical treatment is needed for these types of burns.
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Second-Degree Burns or Partial-Thickness Burns affect the outer layer of the skin or epidermis and the lower layer of the dermis. Examples of these burns could be from boiling water, chemical heat packs, curling irons, or friction burns. Typically, no medical treatment is needed, but use your discretion.
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Third-Degree Burns or Full-Thickness Burns go through the lower layer of the skin or dermis and affect deeper tissues. These burns require immediate medical attention and could be caused by prolonged exposure to scalding liquid, flames, or electric or chemical sources.
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Fourth-degree burns go deeper than third-degree burns and can affect your muscles and bones. Nerve endings are damaged or destroyed, so there is no feeling in the burn area. Seek immediate medical attention if you experience this type of burn. Prolonged flame exposure, scalding oils, and electric or chemical sources typically cause these burns.
Types of Wounds and When to Seek Medical Care
There are two main types of wounds: penetrating and closed wounds. They each have their subsections & ranges of severity. Use discretion as to whether your injury is severe enough for medical attention.
When in doubt, get checked out!
Penetrating wounds can be:
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Surgical wounds and incisions
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Puncture wounds
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Thermal, chemical, or electric burns
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Bites and stings
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Blunt force trauma
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Abrasions
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Lacerations
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Skin tears
Closed wound examples are:
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Contusions
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Blisters
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Seroma
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Hematoma
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Crush injuries
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Ulcers
How to Use Manuka Honey for Burns & Wounds
First, the area must be cleaned. You can do this with a diluted honey & water mixture or a saline solution.
Next, you apply the honey to the injury. You can do this either:
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Directly by simply coating the area with clean or gloved hands
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By adding it to a sterile bandage first & then applying it to the injury
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Or by mixing the honey with a carrier oil (we like castor for this purpose) to create a thinner solution that can be applied directly to the injury without needing to cover it. Note that if you do not cover the area with a bandage, make sure any clothing that goes over it is clean.
A Complement to Modern Wound Care
While more large-scale human studies are still needed, existing evidence supports what traditional use has suggested for centuries: when properly sourced and applied, Manuka honey may serve as a beneficial complement to modern wound and burn care [1][2][3].
Serious burns or deep wounds should always be evaluated by a healthcare professional.
References / Further Reading
1 - Porcine burn wound study – Manuka honey enhanced re-epithelialization and collagen deposition in burn wounds. PubMed ID: 40143075. https://pubmed.ncbi.nlm.nih.gov/40143075/?utm_source=chatgpt.com
2 - Rabbit burn wound study – Topical Manuka honey improved wound closure and tissue quality compared to controls. PubMed ID: 35711790. https://pubmed.ncbi.nlm.nih.gov/35711790/?utm_source=chatgpt.com
3 - Chronic wound clinical case series – Patients with non-healing wounds showed significant depth reduction and complete epithelialization after treatment with Manuka honey dressings. PubMed ID: 34483582. https://pubmed.ncbi.nlm.nih.gov/34483582/?utm_source=chatgpt.com